GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs6988636 | 1 | rs58741168 | chr8:124191852 | FAM83A | chr8:124191287-124222317:+ | -0.27 | -3.66 | 0.000276 | Urinary uromodulin levels |
| THCA | cis | rs58749629 | 1 | rs58749629 | chr20:44571317 | KCNS1 | chr20:43720951-43729753:- | -0.29 | -4.28 | 2.27E-5 | Abdominal aortic aneurysm |
| THCA | cis | rs58749629 | 1 | rs58749629 | chr20:44571317 | WFDC3 | chr20:44402847-44420547:- | -0.42 | -5.78 | 1.35E-8 | Abdominal aortic aneurysm |
| THCA | cis | rs2129782 | 1 | rs58754325 | chr8:89441440 | MMP16 | chr8:89049462-89339717:- | 0.33 | 5.31 | 1.72E-7 | Electrodermal activity |
| THCA | cis | rs2036707 | 1 | rs58806855 | chr13:108484069 | FAM155A | chr13:107820880-108519460:- | 0.48 | 5.61 | 3.46E-8 | Obesity-related traits |
| THCA | cis | rs1027730 | 1 | rs58813232 | chr8:94080505 | C8orf83 | chr8:93895865-94029901:- | 0.28 | 4.45 | 1.07E-5 | Attention deficit hyperactivity disorder |
| THCA | cis | rs2288884 | 1 | rs58817690 | chr19:52536692 | ZNF432 | chr19:52536678-52552073:- | -0.18 | -4.53 | 7.59E-6 | Bronchodilator response in asthma (inhaled corticosteroid treatment interaction) |
| THCA | cis | rs7769051 | 1 | rs58832890 | chr6:133127139 | C6orf192 | chr6:133090507-133119747:- | -0.24 | -3.93 | 9.74E-5 | Type 2 diabetes nephropathy |
| THCA | cis | rs1027730 | 1 | rs58858275 | chr8:94080504 | C8orf83 | chr8:93895865-94029901:- | 0.26 | 4.07 | 5.41E-5 | Attention deficit hyperactivity disorder |
| THCA | cis | rs7112513 | 1 | rs588918 | chr11:116856642 | PCSK7 | chr11:117075789-117102811:- | -0.32 | -5.63 | 3.06E-8 | Protein quantitative trait loci |
| THCA | cis | rs2241437 | 1 | rs58898686 | chr2:86216909 | POLR1A | chr2:86253453-86333278:- | -0.33 | -4.53 | 7.35E-6 | Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) |
| THCA | cis | rs35123781 | 1 | rs589153 | chr5:139057548 | DNAJC18 | chr5:138747381-138775139:- | 0.16 | 3.73 | 0.000218 | Schizophrenia |
| THCA | cis | rs3136441 | 1 | rs58922799 | chr11:46725196 | ARHGAP1 | chr11:46698634-46722120:- | -0.18 | -3.37 | 0.000803 | HDL cholesterol |
| THCA | cis | rs3136441 | 1 | rs58922799 | chr11:46725196 | ZNF408 | chr11:46722368-46727461:+ | -0.18 | -3.42 | 0.000672 | HDL cholesterol |
| THCA | cis | rs8030605 | 1 | rs58934221 | chr15:56516381 | MNS1 | chr15:56720929-56757335:- | -0.24 | -3.5 | 0.000511 | Waist-to-hip ratio adjusted for body mass index |